Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLKL | Q8NB16 | 4/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9427505 | 0.82 | ALOX5 (0.46) | MLKLGAASMN1; SMN2LMNANPC1 | |
| SCHEMBL5532731 | 0.79 | NPC1 (0.54) | MLKLIDO1GAASMN1; SMN2LMNA | |
| SCHEMBL9428125 | 0.78 | LMNA (0.41) | MLKLIDO1GAASMN1; SMN2LMNA | |
| SCHEMBL5530550 | 0.77 | RAB9A (0.58) | IDO1GAASMN1; SMN2LMNAALOX12 | |
| SCHEMBL29537224 | 0.74 | IDO1 (0.72) | MLKLIDO1GAASMN1; SMN2LMNA | |
| SCHEMBL2673705 | 0.74 | IDO1 (0.72) | MLKLIDO1GAASMN1; SMN2LMNA | |
| SCHEMBL250817 | 0.74 | IDO1 (0.72) | MLKLIDO1GAASMN1; SMN2LMNA | |
| SCHEMBL2674618 | 0.74 | IDO1 (0.72) | MLKLIDO1GAASMN1; SMN2LMNA | |
| SCHEMBL3617238 | 0.74 | ADAMTS4 (0.60) | — | |
| SCHEMBL4031376 | 0.74 | LMNA (0.43) | MLKLIDO1GAASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5364944-A | Antiinflammatory, antiallergic and cytoprotective agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-11-15 | — | — | US | disclosed |
| US-5218124-A | Antiinflammatory agents, antiallergens and cytoprotective agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-06-08 | — | — | US | disclosed |