Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | PTAFR | P25105 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9407110 | 0.86 | PBRM1 (0.37) | RIPK1HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL8782099 | 0.83 | HTR2A (0.44) | ACHEHTR2AHTR2CHTR2BHDAC1 | |
| SCHEMBL9427669 | 0.77 | TSHR (0.38) | TSHRRIPK1USP2 | |
| SCHEMBL28922654 | 0.72 | ACHE (0.50) | ACHEHTR2AHTR2CHTR2BMETAP1 | |
| SCHEMBL28922605 | 0.72 | ACHE (0.50) | ACHEHTR2AHTR2CHTR2BMETAP1 | |
| SCHEMBL10085914 | 0.70 | NPC1 (0.56) | TSHRHDAC1HDAC4HDAC6PTAFR | |
| SCHEMBL9429146 | 0.70 | HRH3 (0.36) | HTR2AHTR2CRIPK1 | |
| SCHEMBL8783196 | 0.66 | ESR1 (0.45) | ACHEHTR2AHTR2CHTR2BMAPT | |
| SCHEMBL435024 | 0.65 | ACHE (0.45) | ACHEHTR2AHTR2CHTR2BMETAP1 | |
| SCHEMBL8782370 | 0.65 | DRD2 (0.39) | HTR2AHTR2CRIPK1HDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5330991-A | Tetrahydroisoquinoline compounds and fungicides containing the same | TOSOH CORPORATION (JP) | 1994-07-19 | — | — | US | disclosed |
| EP-0528553-A1 | Tetrahydroisoquinoline derivatives, processes for producing the same and fungicides containing the same | TOSOH CORPORATION (JP) | 1993-02-24 | — | — | EP | disclosed |