Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9429463 | 0.90 | PTGS2 (0.52) | PTGS2HTTSMN1; SMN2FLT1KDR | |
| SCHEMBL9429341 | 0.89 | MAPT (0.58) | MAPTHTTSMN1; SMN2FLT1KDR | |
| SCHEMBL9429300 | 0.88 | SMN1; SMN2 (0.52) | PTGS2HTTSMN1; SMN2FLT1KDR | |
| SCHEMBL9429944 | 0.86 | KDM4E (0.53) | PTGS2MAPTHTTSMN1; SMN2TP53 | |
| SCHEMBL9423132 | 0.86 | HTT (0.64) | PTGS2MAPTHTTSMN1; SMN2FLT1 | |
| SCHEMBL9423016 | 0.80 | PTGS2 (0.51) | PTGS2MAPTHTTSMN1; SMN2FLT1 | |
| SCHEMBL9429402 | 0.80 | PTGS2 (0.58) | PTGS2MAPTHTTSMN1; SMN2FLT1 | |
| SCHEMBL9429412 | 0.79 | HIF1A (0.56) | MAPTSMN1; SMN2TP53POLBNPC1 | |
| SCHEMBL9428794 | 0.79 | PTGS2 (0.58) | PTGS2MAPTHTTSMN1; SMN2FLT1 | |
| SCHEMBL9428554 | 0.79 | PTGS1 (0.50) | MAPTHTTSMN1; SMN2FLT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328907-A | Treatment of allograft rejection in mammals and antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1994-07-12 | — | — | US | disclosed |
| US-5108999-A | For treating inflammation, autoimmune disease or allograft rejection in mammals | SYNTEX (U.S.A.) INC. (US) | 1992-04-28 | — | — | US | disclosed |
| US-5001124-A | 4-isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-03-19 | — | — | US | disclosed |