Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | RORC | P51449 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9429341 | 0.90 | MAPT (0.58) | NPC1RAB9ARORCTRPV1MAPT | |
| SCHEMBL9429463 | 0.88 | PTGS2 (0.52) | PTGS1RORCTRPV1TP53HTT | |
| SCHEMBL9429412 | 0.85 | HIF1A (0.56) | PTGS1NPC1RAB9AMAPTLMNA | |
| SCHEMBL9428463 | 0.85 | KDM4E (0.54) | PTGS1NPC1RAB9ARORCMAPT | |
| SCHEMBL9428482 | 0.83 | HTT (0.54) | NPC1RAB9ATRPV1MAPTCISD2 | |
| SCHEMBL9429300 | 0.79 | SMN1; SMN2 (0.52) | RORCTRPV1TP53HTTSMN1; SMN2 | |
| SCHEMBL9428655 | 0.79 | PTGS2 (0.51) | NPC1RAB9ATRPV1MAPTTP53 | |
| SCHEMBL9429262 | 0.77 | PTGS2 (0.49) | NPC1RAB9ATRPV1MAPTGMNN | |
| SCHEMBL9429668 | 0.77 | HIF1A (0.57) | PTGS1NPC1RAB9AMAPTLMNA | |
| SCHEMBL1806543 | 0.76 | PTGS1 (0.55) | PTGS1TRPV1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328907-A | Treatment of allograft rejection in mammals and antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1994-07-12 | — | — | US | disclosed |
| US-5108999-A | For treating inflammation, autoimmune disease or allograft rejection in mammals | SYNTEX (U.S.A.) INC. (US) | 1992-04-28 | — | — | US | disclosed |
| US-5001124-A | 4-isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-03-19 | — | — | US | disclosed |