Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ACR | P10323 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GHSR | Q92847 | 2/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9428463 | 0.89 | KDM4E (0.54) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL9429341 | 0.87 | MAPT (0.58) | MAPTHTTTP53SMN1; SMN2NPC1 | |
| SCHEMBL9428655 | 0.86 | PTGS2 (0.51) | MAPTHTTMEN1KMT2ATP53 | |
| SCHEMBL9429043 | 0.84 | HTT (0.65) | KDM4EMAPTHTTMEN1KMT2A | |
| SCHEMBL768777 | 0.80 | PTGS1 (0.51) | KDM4EMAPTHTTMEN1KMT2A | |
| SCHEMBL2565415 | 0.78 | PTGS1 (0.52) | KDM4EMAPTHTTMEN1KMT2A | |
| SCHEMBL9429412 | 0.78 | HIF1A (0.56) | KDM4EMAPTALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL16110874 | 0.77 | PTGS1 (0.48) | KDM4EMAPTHTTMEN1KMT2A | |
| SCHEMBL1686237 | 0.75 | TARBP2 (0.56) | KDM4EMAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL1686242 | 0.75 | TARBP2 (0.56) | KDM4EMAPTALDH1A1TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328907-A | Treatment of allograft rejection in mammals and antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1994-07-12 | — | — | US | disclosed |
| US-5108999-A | For treating inflammation, autoimmune disease or allograft rejection in mammals | SYNTEX (U.S.A.) INC. (US) | 1992-04-28 | — | — | US | disclosed |
| US-5001124-A | 4-isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-03-19 | — | — | US | disclosed |