Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9428554 | 0.90 | PTGS1 (0.50) | MAPTHTTTP53DHODHTRPV1 | |
| SCHEMBL9428655 | 0.89 | PTGS2 (0.51) | MAPTHTTTP53TRPV1SMN1; SMN2 | |
| SCHEMBL9429944 | 0.87 | KDM4E (0.53) | MAPTHTTTP53DHODHSMN1; SMN2 | |
| SCHEMBL9428786 | 0.85 | HTT (0.65) | MAPTHTTTP53DHODHSMN1; SMN2 | |
| SCHEMBL9423064 | 0.80 | MAPT (0.58) | MAPTHTTTP53DHODHSMN1; SMN2 | |
| SCHEMBL9429928 | 0.80 | HTT (0.53) | MAPTHTTTP53DHODHSMN1; SMN2 | |
| SCHEMBL9429908 | 0.79 | HTT (0.57) | MAPTHTTTP53DHODHSMN1; SMN2 | |
| SCHEMBL9429463 | 0.78 | PTGS2 (0.52) | HTTTP53TRPV1SMN1; SMN2RORC | |
| SCHEMBL9429927 | 0.78 | HTT (0.56) | MAPTHTTTP53DHODHSMN1; SMN2 | |
| SCHEMBL768777 | 0.78 | PTGS1 (0.51) | MAPTHTTSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328907-A | Treatment of allograft rejection in mammals and antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1994-07-12 | — | — | US | disclosed |
| US-5108999-A | For treating inflammation, autoimmune disease or allograft rejection in mammals | SYNTEX (U.S.A.) INC. (US) | 1992-04-28 | — | — | US | disclosed |
| US-5001124-A | 4-isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-03-19 | — | — | US | disclosed |