Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 4/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 9/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9428761 | 0.96 | MEN1 (0.49) | KCNJ1KCNH2MEN1ALDH1A1KMT2A | |
| SCHEMBL9428870 | 0.86 | HRH3 (0.57) | MEN1ALDH1A1KMT2AHRH1 | |
| SCHEMBL9429616 | 0.85 | HRH3 (0.58) | MEN1ALDH1A1KMT2AHRH1 | |
| SCHEMBL9429541 | 0.84 | SIGMAR1 (0.52) | MEN1ALDH1A1KMT2AHRH1HTR1A | |
| SCHEMBL9429307 | 0.84 | SIGMAR1 (0.58) | MEN1ALDH1A1KMT2AHRH1ADRA1D | |
| Hydrochloric Acid SCHEMBL9428790 | 0.83 | SIGMAR1 (0.51) | MEN1ALDH1A1KMT2AHRH1HTR1A | |
| Hydrochloric Acid SCHEMBL9429389 | 0.83 | SIGMAR1 (0.56) | MEN1ALDH1A1KMT2AHRH1OPRM1 | |
| SCHEMBL9429273 | 0.81 | HTR1A (0.51) | MEN1ALDH1A1KMT2AHRH1HTR1A | |
| SCHEMBL9428701 | 0.81 | SIGMAR1 (0.58) | MEN1ALDH1A1KMT2AHRH1ADRA1D | |
| SCHEMBL9383628 | 0.81 | KCNJ1 (0.63) | KCNJ1KCNH2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332739-A | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1994-07-26 | — | — | US | disclosed |
| EP-0454498-A2 | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-10-30 | — | — | EP | disclosed |