Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | GHSR | Q92847 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9428918 | 0.89 | HTT (0.67) | HTTALDH1A1TP53MAPTMEN1 | |
| SCHEMBL9422982 | 0.87 | HTT (0.68) | HTTALDH1A1GHSRTP53MAPT | |
| SCHEMBL9429860 | 0.87 | HTT (0.64) | HTTALDH1A1TP53MAPTKDM4E | |
| SCHEMBL9423028 | 0.85 | HTT (0.62) | HTTALDH1A1TP53MAPTKDM4E | |
| SCHEMBL9428786 | 0.85 | HTT (0.65) | HTTALDH1A1TP53MAPTLMNA | |
| SCHEMBL9429944 | 0.84 | KDM4E (0.53) | HTTALDH1A1GHSRTP53MAPT | |
| SCHEMBL9423132 | 0.84 | HTT (0.64) | HTTALDH1A1TP53MAPTMEN1 | |
| SCHEMBL9422920 | 0.84 | HTT (0.61) | HTTALDH1A1GHSRTP53MAPT | |
| SCHEMBL9429690 | 0.83 | GPBAR1 (0.60) | GHSRMEN1KMT2AKDM4EGPBAR1 | |
| SCHEMBL9423200 | 0.82 | HTT (0.61) | HTTALDH1A1TP53MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328907-A | Treatment of allograft rejection in mammals and antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1994-07-12 | — | — | US | disclosed |
| US-5108999-A | For treating inflammation, autoimmune disease or allograft rejection in mammals | SYNTEX (U.S.A.) INC. (US) | 1992-04-28 | — | — | US | disclosed |
| US-5001124-A | 4-isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-03-19 | — | — | US | disclosed |