Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | GHSR | Q92847 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8376637 | 0.85 | LMNA (0.57) | GPBAR1LMNARECQLPTGS2MEN1 | |
| SCHEMBL9871174 | 0.84 | PTGS2 (0.62) | LMNARECQLPTGS2NPC1RAB9A | |
| SCHEMBL9429244 | 0.84 | NPC1 (0.56) | LMNARECQLPTGS2NPC1RAB9A | |
| SCHEMBL9429043 | 0.83 | HTT (0.65) | GPBAR1LMNAGHSRKDM4ENPC1 | |
| SCHEMBL8375488 | 0.83 | LMNA (0.54) | LMNARECQLPTGS2KDM4ESMN1; SMN2 | |
| SCHEMBL7880670 | 0.83 | LMNA (0.56) | LMNARECQLPTGS2NPC1RAB9A | |
| SCHEMBL8377819 | 0.82 | KMT2A (0.54) | LMNARECQLGHSRNPC1RAB9A | |
| SCHEMBL8375473 | 0.80 | PTGS2 (0.65) | LMNARECQLPTGS2NPC1RAB9A | |
| SCHEMBL8379618 | 0.80 | LMNA (0.54) | LMNARECQLPTGS2NPC1RAB9A | |
| SCHEMBL8379472 | 0.79 | LMNA (0.56) | LMNARECQLKDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328907-A | Treatment of allograft rejection in mammals and antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1994-07-12 | — | — | US | disclosed |
| US-5108999-A | For treating inflammation, autoimmune disease or allograft rejection in mammals | SYNTEX (U.S.A.) INC. (US) | 1992-04-28 | — | — | US | disclosed |
| US-5001124-A | 4-isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-03-19 | — | — | US | disclosed |