Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9042004 | 0.86 | ALDH1A1 (0.45) | FFAR1SLC6A4SLC6A2SLC6A3CYP4F2 | |
| SCHEMBL2558706 | 0.86 | SLC6A4 (0.54) | TBXAS1PKMSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL9429974 | 0.86 | SLC6A4 (0.54) | TBXAS1PKMSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL28575436 | 0.86 | SLC6A2 (0.49) | TBXAS1PKMSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2557868 | 0.84 | TBXAS1 (0.46) | TBXAS1PKMSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL1146416 | 0.84 | HTR2A (0.54) | TBXAS1PKMSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL6651903 | 0.81 | SLC6A4 (0.56) | TBXAS1PKMSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2562349 | 0.80 | LMNA (0.47) | TBXAS1PKMMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL1643059 | 0.79 | F10 (0.46) | PKMFFAR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11511051 | 0.79 | HTR2A (0.48) | TBXAS1SLC6A4SLC6A2SLC6A3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5373015-A | Treating hypertension and congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-12-13 | — | — | US | disclosed |
| EP-0539066-A1 | Heterocyclic compounds useful as angiotensin II antagonists | ZENECA LIMITED (GB) | 1993-04-28 | — | — | EP | disclosed |