Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | P2RY10 | O00398 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28575436 | 0.91 | SLC6A2 (0.49) | SLC6A4TBXAS1PKMMAPTSLC6A2 | |
| SCHEMBL1146416 | 0.89 | HTR2A (0.54) | SLC6A4HTR2ATBXAS1PKMMAPT | |
| SCHEMBL2558706 | 0.89 | SLC6A4 (0.54) | SLC6A4HTR2ATBXAS1PKMMAPT | |
| SCHEMBL2557868 | 0.89 | TBXAS1 (0.46) | SLC6A4HTR2ATBXAS1PKMMAPT | |
| SCHEMBL6935863 | 0.87 | SLC6A4 (0.55) | SLC6A4HTR2AMAPTHTTSLC6A2 | |
| SCHEMBL9429751 | 0.86 | TBXAS1 (0.44) | SLC6A4HTR2ATBXAS1PKMMAPT | |
| SCHEMBL6651903 | 0.85 | SLC6A4 (0.56) | SLC6A4TBXAS1PKMMAPTSLC6A2 | |
| SCHEMBL2562349 | 0.84 | LMNA (0.47) | TBXAS1PKMMAPTLMNAPOLB | |
| SCHEMBL11511051 | 0.83 | HTR2A (0.48) | SLC6A4HTR2ATBXAS1MAPTSLC6A2 | |
| SCHEMBL5024669 | 0.81 | SLC6A4 (0.67) | SLC6A4HTR2AMAPTHTTSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5373015-A | Treating hypertension and congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-12-13 | — | — | US | disclosed |
| EP-0539066-A1 | Heterocyclic compounds useful as angiotensin II antagonists | ZENECA LIMITED (GB) | 1993-04-28 | — | — | EP | disclosed |