Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.55 |
| ▸ | HTR2A | P28223 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7254516 | 0.89 | SLC6A4 (0.56) | SLC6A4HTR2AMAPTHTTSLC6A2 | |
| SCHEMBL837233 | 0.89 | RIPK1 (0.51) | SLC6A4SLC6A2TDP1L3MBTL1MEN1 | |
| SCHEMBL9429974 | 0.87 | SLC6A4 (0.54) | SLC6A4HTR2AMAPTHTTNPC1 | |
| SCHEMBL2248000 | 0.87 | HTR2A (0.60) | SLC6A4HTR2AMAPTHTTSLC6A2 | |
| SCHEMBL10093148 | 0.87 | SLC6A4 (0.43) | SLC6A4HTR2AHTTSLC6A2SLC6A3 | |
| SCHEMBL9042004 | 0.84 | ALDH1A1 (0.45) | SLC6A4HTR2ASLC6A2SLC6A3TDP1 | |
| SCHEMBL9150938 | 0.82 | KDM4E (0.48) | SLC6A4HTTSLC6A2MEN1KMT2A | |
| SCHEMBL8944629 | 0.81 | TSPO (0.44) | SLC6A4SLC6A2TDP1L3MBTL1CXCL8 | |
| SCHEMBL9128207 | 0.80 | HTR2A (0.63) | SLC6A4HTR2AMAPTLMNA | |
| SCHEMBL8002569 | 0.79 | MTNR1B (0.54) | TDP1L3MBTL1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566547-B1 | 3-alkoxy-2-phenylacrylic acid derivatives | ZENECA LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-0178826-B2 | Fungicides | SYNGENTA LTD (GB) | 2003-04-09 | — | — | EP | disclosed |
| EP-0515535-A4 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO INC (US) | 1996-01-17 | — | — | EP | disclosed |
| EP-0517812-A4 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO INC (US) | 1995-10-18 | — | — | EP | disclosed |
| US-5449682-A | Angiotensin II antagonists incorporating a substituted benzyl element | MERCK & CO., INC. (US) | 1995-09-12 | — | — | US | disclosed |
| US-5420133-A | Quinazolinones substituted with phenoxyphenylacetic acid derivatives | MERCK & CO., INC. (US) | 1995-05-30 | — | — | US | disclosed |
| US-5373015-A | Treating hypertension and congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-12-13 | — | — | US | disclosed |
| US-5315025-A | Acrylate ethers | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-05-24 | — | — | US | disclosed |
| US-5286894-A | Phenyl acrylic acid derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-02-15 | — | — | US | disclosed |
| US-5264439-A | Quinazolinone, triazolinone and pyrimidinone angiotensin II antagonists incorporating a substituted benzyl element | MERCK & CO., INC. (US) | 1993-11-23 | — | — | US | disclosed |
| US-5240938-A | Angiotensin II antagonists incorporating a substituted pyridoimidazolyl ring | MERCK & CO., INC. (US) | 1993-08-31 | — | — | US | disclosed |
| EP-0539066-A1 | Heterocyclic compounds useful as angiotensin II antagonists | ZENECA LIMITED (GB) | 1993-04-28 | — | — | EP | disclosed |
| EP-0517812-A1 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO. INC. (US) | 1992-12-16 | — | — | EP | disclosed |
| EP-0515535-A1 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO. INC. (US) | 1992-12-02 | — | — | EP | disclosed |
| EP-0178826-B1 | FUNGICIDES | ZENECA LIMITED (GB) | 1991-12-18 | — | — | EP | disclosed |
| WO-1991011999-A1 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO., INC. (US) | 1991-08-22 | — | — | WO | disclosed |
| WO-1991012001-A1 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO., INC. (US) | 1991-08-22 | — | — | WO | disclosed |
| EP-0431328-A2 | Fungicides | ZENECA LIMITED (GB) | 1991-06-12 | — | — | EP | disclosed |
| EP-0178826-A2 | Fungicides | ZENECA LIMITED (GB) | 1986-04-23 | — | — | EP | disclosed |