Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10979533 | 0.93 | L3MBTL1 (0.54) | SMN1; SMN2GLACSNK2A1BACE1S1PR1 | |
| SCHEMBL6505491 | 0.92 | GLA (0.51) | SMN1; SMN2GLACSNK2A1BACE1S1PR1 | |
| SCHEMBL10983103 | 0.92 | SMN1; SMN2 (0.58) | SMN1; SMN2GLACSNK2A1BACE1S1PR1 | |
| SCHEMBL9399929 | 0.91 | THRA (0.53) | SMN1; SMN2GLACSNK2A1BACE1S1PR1 | |
| SCHEMBL9398890 | 0.91 | THRA (0.53) | SMN1; SMN2GLACSNK2A1BACE1S1PR1 | |
| SCHEMBL10974737 | 0.91 | SMN1; SMN2 (0.61) | SMN1; SMN2GLACSNK2A1BACE1S1PR1 | |
| SCHEMBL10980032 | 0.91 | SMN1; SMN2 (0.61) | SMN1; SMN2GLACSNK2A1BACE1S1PR1 | |
| SCHEMBL10980962 | 0.89 | SMN1; SMN2 (0.59) | SMN1; SMN2GLACSNK2A1BACE1S1PR1 | |
| SCHEMBL9399173 | 0.89 | SMN1; SMN2 (0.59) | SMN1; SMN2GLACSNK2A1BACE1S1PR1 | |
| SCHEMBL10979485 | 0.89 | MAPT (0.52) | SMN1; SMN2GLACSNK2A1BACE1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5338483-A | Anisotropic compounds having nematic phase and liquid crystal mixtures | MERCK PATENT GMBH (DE) | 1994-08-16 | — | — | US | disclosed |
| US-5227484-A | ANISOTROPIC COMPOUNDS HAVING NEMATIC PHASE AND LIQUID CRYSTAL MIXTURES | MERCK PATENT GMBH (DE) | 1993-07-13 | — | — | US | disclosed |
| US-5047170-A | Anisotropic compounds having nematic phase and liquid crystal mixtures | MERCK PATENT GMBH (DE) | 1991-09-10 | — | — | US | disclosed |
| US-4808333-A | Anisotropic compounds having nematic phase and liquid crystal mixtures | MERCK PATENT GMBH (DE) | 1989-02-28 | — | — | US | disclosed |