Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 8/20 | 0.76 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4832048 | 0.89 | HTR7 (0.69) | HTR7GAAMAPTSMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL2140664 | 0.82 | HTR7 (0.69) | HTR7ALDH1A1TP53HTR6MEN1 | |
| Hydrochloric Acid SCHEMBL4232329 | 0.81 | HTR7 (0.70) | HTR7ALDH1A1TP53HTR6MEN1 | |
| SCHEMBL9433739 | 0.81 | HTR7 (0.74) | HTR7KDM4ETP53OPRK1HTR6 | |
| Hydrochloric Acid SCHEMBL4230045 | 0.80 | HTR7 (0.69) | HTR7ALDH1A1TP53HTR6MEN1 | |
| SCHEMBL15823836 | 0.80 | GAA (0.74) | GAAMAPTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL7648765 | 0.80 | ALDH1A1 (0.54) | HTR7GAAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7000216 | 0.80 | KDM4E (0.92) | GAAMAPTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL5741137 | 0.79 | HTR7 (1.00) | HTR7KDM4EHTR6 | |
| SCHEMBL4772036 | 0.79 | KDM4E (0.90) | GAAMAPTSMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294621-A | Thieno tetrahydropyridines useful as class III antiarrhythmic agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-03-15 | — | — | US | disclosed |