Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9433754 | 0.87 | GAA (0.44) | POLBSMN1; SMN2CACNA1BALDH1A1LMNA | |
| SCHEMBL9434441 | 0.84 | MEN1 (0.45) | CYP11B1CYP11B2CYP19A1POLBCACNA1B | |
| SCHEMBL9434190 | 0.84 | CACNA1B (0.59) | CACNA1BALDH1A1 | |
| SCHEMBL10961726 | 0.83 | POLB (0.54) | POLBSMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL9433779 | 0.83 | POLB (0.47) | POLBSMN1; SMN2SGMS2ALDH1A1HSD17B10 | |
| SCHEMBL9433545 | 0.82 | CACNA1B (0.44) | CACNA1BALDH1A1LMNAKDM4EGAA | |
| SCHEMBL9433577 | 0.81 | PKM (0.47) | CACNA1BKDM4E | |
| SCHEMBL9434851 | 0.80 | KDM4E (0.44) | CACNA1BALDH1A1KDM4E | |
| SCHEMBL9434792 | 0.80 | CACNA1B (0.43) | CACNA1BALDH1A1GAA | |
| SCHEMBL9433824 | 0.80 | CACNA1B (0.43) | CACNA1BALDH1A1LMNAHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5276150-A | Vasodilators, anticoagulants, calcium channel blockers | FUJIREBIO INC. (JP) | 1994-01-04 | — | — | US | disclosed |
| EP-0400660-A1 | 1,4-dihydropyridine derivatives | FUJIREBIO INC. (JP) | 1990-12-05 | — | — | EP | disclosed |