Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 11/20 | 0.91 |
| ▸ | NPC1 | O15118 | 6/20 | 0.89 |
| ▸ | RAB9A | P51151 | 6/20 | 0.89 |
| ▸ | LMNA | P02545 | 4/20 | 0.89 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.89 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.89 |
| ▸ | GAA | P10253 | 2/20 | 0.89 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9199162 | 0.95 | WDR5 (1.00) | WDR5NPC1RAB9ALMNAKMT2A | |
| SCHEMBL10749972 | 0.85 | WDR5 (0.69) | WDR5NPC1RAB9ALMNAKMT2A | |
| SCHEMBL18281469 | 0.82 | LMNA (0.94) | WDR5NPC1RAB9ALMNAKMT2A | |
| SCHEMBL24264985 | 0.82 | WDR5 (0.63) | WDR5NPC1RAB9ALMNAKMT2A | |
| Hydrochloric Acid SCHEMBL5301356 | 0.81 | LMNA (0.67) | WDR5NPC1RAB9ALMNAKMT2A | |
| Hydrochloric Acid SCHEMBL30309713 | 0.81 | ALDH1A1 (0.63) | WDR5NPC1RAB9ALMNAKMT2A | |
| Hydrochloric Acid SCHEMBL5300777 | 0.81 | LMNA (0.97) | WDR5NPC1RAB9ALMNAKMT2A | |
| SCHEMBL9698908 | 0.80 | LMNA (0.70) | WDR5NPC1RAB9ALMNAKMT2A | |
| SCHEMBL5308466 | 0.80 | ALDH1A1 (0.70) | WDR5NPC1RAB9ALMNAKMT2A | |
| SCHEMBL5778043 | 0.80 | LMNA (0.70) | WDR5NPC1RAB9ALMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231622-B1 | Inhibition of the 5-lipoxygenase pathway | SMITHKLINE BEECHAM CORP (US) | 1994-08-24 | — | — | EP | disclosed |
| WO-1990003789-A1 | PYRROLO[1,2-a]IMIDAZOLE AND IMIDAZO[1,2-a]PYRIDINE DERIVATIVES AND THEIR USE AS 5-LYPOXYGENASE PATHWAY INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-04-19 | — | — | WO | disclosed |
| EP-0364204-A1 | Pyrrolo[1,2-a]imidazole and imidazo[1,2-a]pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1990-04-18 | — | — | EP | disclosed |
| EP-0231622-A2 | Inhibition of the 5-lipoxygenase pathway | SMITHKLINE BEECHAM CORPORATION (US) | 1987-08-12 | — | — | EP | disclosed |