Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTO1 | P78417 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 6/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ACLY | P53396 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13543489 | 0.92 | MAPT (0.73) | GSTO1MAPTPOLBL3MBTL1TDP1 | |
| SCHEMBL11595503 | 0.86 | POLB (0.56) | GSTO1MAPTPOLBL3MBTL1TDP1 | |
| SCHEMBL9436722 | 0.83 | POLB (0.58) | MAPTPOLBL3MBTL1TDP1HSD17B10 | |
| SCHEMBL11710034 | 0.82 | MAPT (0.56) | GSTO1MAPTPOLBL3MBTL1TDP1 | |
| SCHEMBL13543285 | 0.80 | GSTO1 (0.62) | GSTO1MAPTPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL9436763 | 0.78 | MAPT (0.55) | MAPTPOLBL3MBTL1TDP1HSD17B10 | |
| SCHEMBL11596502 | 0.77 | AKR1C3 (0.62) | POLBL3MBTL1TDP1HSD17B10ALDH1A1 | |
| SCHEMBL7658881 | 0.77 | MAPT (1.00) | MAPTPOLBL3MBTL1TDP1KDM4E | |
| SCHEMBL11555586 | 0.75 | GAA (0.50) | GSTO1POLBL3MBTL1TDP1HSD17B10 | |
| SCHEMBL11026357 | 0.75 | POLB (0.65) | GSTO1MAPTPOLBL3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292755-A | USPA benzolyguanidines | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-03-08 | — | — | US | disclosed |
| US-5091394-A | BENZOYLGUANIDINES, A PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND MEDICAMENTS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-02-25 | — | — | US | disclosed |