Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 12/20 | 0.48 |
| ▸ | CA1 | P00915 | 11/20 | 0.48 |
| ▸ | CA9 | Q16790 | 10/20 | 0.48 |
| ▸ | CA12 | O43570 | 9/20 | 0.48 |
| ▸ | CA4 | P22748 | 8/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 8/20 | 0.48 |
| ▸ | CA7 | P43166 | 8/20 | 0.48 |
| ▸ | CA13 | Q8N1Q1 | 8/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10651357 | 0.82 | HPGD (0.58) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL11549637 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL11665329 | 0.79 | ALDH1A1 (0.55) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL6516445 | 0.79 | MAPT (0.55) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL10651004 | 0.79 | L3MBTL1 (0.58) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL9189602 | 0.79 | CA2 (0.47) | MAPTGAACA2CA1CA9 | |
| SCHEMBL25465981 | 0.78 | ALDH1A1 (0.59) | KDM4EALDH1A1HPGDMAPTLMNA | |
| Hydrochloric Acid SCHEMBL9196592 | 0.78 | CA2 (0.46) | MAPTGAACA2CA1CA9 | |
| SCHEMBL18424511 | 0.77 | CA2 (0.65) | CA2CA1CA9CA12CA4 | |
| SCHEMBL9436755 | 0.77 | PTGS2 (0.60) | KDM4EALDH1A1HPGDPKMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292755-A | USPA benzolyguanidines | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-03-08 | — | — | US | disclosed |
| US-5091394-A | BENZOYLGUANIDINES, A PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND MEDICAMENTS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-02-25 | — | — | US | disclosed |