Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7333712 | 0.88 | REN (0.41) | LMNASMN1; SMN2ALDH1A1KMT2AREN | |
| SCHEMBL7325021 | 0.88 | REN (0.41) | LMNASMN1; SMN2ALDH1A1KMT2AREN | |
| SCHEMBL9437647 | 0.85 | CTSS (0.35) | ALDH1A1KMT2ARENCTSSMAPT | |
| SCHEMBL9437587 | 0.83 | LMNA (0.44) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9437581 | 0.82 | CTSS (0.35) | KMT2ARENCTSS | |
| SCHEMBL9437551 | 0.81 | MEN1 (0.45) | SMN1; SMN2ALDH1A1MEN1KMT2AREN | |
| SCHEMBL8909332 | 0.79 | LMNA (0.56) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL7301756 | 0.79 | LMNA (0.56) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9437644 | 0.78 | LMNA (0.41) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9437606 | 0.76 | LMNA (0.45) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |