Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.49 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | HTR1D | P28221 | 2/20 | 0.47 |
| ▸ | HTR1B | P28222 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.46 |
| ▸ | DRD2 | P14416 | 7/20 | 0.43 |
| ▸ | DRD4 | P21917 | 7/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9437890 | 0.87 | HTR1A (0.47) | PARP1HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL9437815 | 0.84 | PARP1 (0.45) | PARP1HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL9437866 | 0.83 | PARP1 (0.53) | PARP1HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL9437900 | 0.82 | PARP1 (0.46) | PARP1HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL9437950 | 0.81 | HTR1A (0.45) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL9437769 | 0.80 | PARP1 (0.47) | PARP1HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL9437847 | 0.80 | PARP1 (0.54) | PARP1HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL9437714 | 0.79 | PARP1 (0.67) | PARP1HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL9437888 | 0.77 | HTR1A (0.49) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL9437860 | 0.76 | PARP1 (0.56) | PARP1HTR1AHTR1DHTR1BSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5296477-A | Antidepressants | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
| US-5268381-A | Antidepressant or anxiolytic compound | ADIR ET COMPAGNIE (FR) | 1993-12-07 | — | — | US | disclosed |
| US-5196434-A | Antidepressants, anxiolytic agents | ADIR ET COMPAGNIE (FR) | 1993-03-23 | — | — | US | disclosed |