Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 15/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9438424 | 0.87 | SIGMAR1 (0.46) | SIGMAR1GAAALDH1A1MEN1MAPT | |
| SCHEMBL6725045 | 0.83 | SIGMAR1 (0.42) | SIGMAR1GAAALDH1A1GLAHTT | |
| SCHEMBL7619847 | 0.82 | SIGMAR1 (0.43) | SIGMAR1GAAMAPT | |
| SCHEMBL8329446 | 0.80 | LMNA (0.41) | SIGMAR1ALDH1A1CYP2D6TSHRMEN1 | |
| SCHEMBL8334409 | 0.79 | SIGMAR1 (0.33) | SIGMAR1 | |
| SCHEMBL7616900 | 0.79 | THRB (0.41) | SIGMAR1GAAALDH1A1HTTTP53 | |
| SCHEMBL9438468 | 0.76 | SIGMAR1 (0.56) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL6719519 | 0.72 | SIGMAR1 (0.53) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL6725049 | 0.71 | SIGMAR1 (0.72) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL6721222 | 0.71 | SIGMAR1 (0.48) | SIGMAR1ALDH1A1TP53CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0517852-A4 | — | — | 1994-03-02 | — | — | EP | disclosed |
| EP-0517852-A1 | TRI- AND TETRA-SUBSTITUTED GUANIDINES AND THEIR USE AS EXCITATORY AMINO ACID ANTAGONISTS | STATE OF OREGON, acting through OREGON STATE BOARD OF HIGHER EDUCATION, acting for OREGON HEALTH SC. UNIV. AND UNIV. OF OREGON (US) | 1992-12-16 | — | — | EP | disclosed |
| WO-1991012797-A1 | TRI- AND TETRA-SUBSTITUTED GUANIDINES AND THEIR USE AS EXCITATORY AMINO ACID ANTAGONISTS | STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALF SCIENCES UNIVERSITY (US) | 1991-09-05 | — | — | WO | disclosed |