Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PGK1 | P00558 | 1/20 | 0.44 |
| ▸ | PGK2 | P07205 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzophenone SCHEMBL16238911 | 0.93 | ALDH1A1 (0.54) | ALDH1A1HPGDRAB9AHTTSMN1; SMN2 | |
| SCHEMBL9440234 | 0.93 | ALDH1A1 (0.54) | ALDH1A1HPGDRAB9AHTTSMN1; SMN2 | |
| Benzylphosphonic Acid SCHEMBL2859455 | 0.84 | ENPP2 (0.56) | HPGDENPP2PGK1PGK2 | |
| SCHEMBL914666 | 0.82 | SRD5A2 (0.58) | ALDH1A1SRD5A2PGK1PGK2 | |
| SCHEMBL915609 | 0.82 | ENPP2 (0.71) | ALDH1A1HPGDENPP2MAPTDGAT2 | |
| Benzophenone SCHEMBL11693944 | 0.80 | ALDH1A1 (0.74) | ALDH1A1HPGDRAB9ASRD5A2MAPT | |
| SCHEMBL915481 | 0.79 | LMNA (0.58) | HPGDENPP2RAB9AHTTSMN1; SMN2 | |
| SCHEMBL3788645 | 0.78 | MEN1 (0.41) | ALDH1A1HPGDRAB9ASRD5A2GAA | |
| SCHEMBL9440266 | 0.78 | ALDH1A1 (0.49) | ALDH1A1HPGDRAB9AHTTSMN1; SMN2 | |
| SCHEMBL16238861 | 0.77 | ALDH1A1 (0.52) | ALDH1A1HPGDRAB9AHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526488-B1 | BENZYLPHOSPHONIC ACID TYROSINE KINASE INHIBITORS | PFIZER (US) | 1994-11-30 | — | — | EP | disclosed |
| US-5326905-A | Benzylphosphonic acid tyrosine kinase inhibitors | PFIZER INC. (US) | 1994-07-05 | — | — | US | disclosed |
| EP-0526488-A1 | BENZYLPHOSPHONIC ACID TYROSINE KINASE INHIBITORS. | PFIZER (US) | 1993-02-10 | — | — | EP | disclosed |
| WO-1991015495-A1 | BENZYLPHOSPHONIC ACID TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1991-10-17 | — | — | WO | disclosed |