Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 13/20 | 0.53 |
| ▸ | MAOA | P21397 | 6/20 | 0.47 |
| ▸ | MAOB | P27338 | 6/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | PTGIR | P43119 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9440693 | 0.83 | NISCH (0.52) | NISCHMAOAMAOBADRA1DADRA1A | |
| SCHEMBL9440600 | 0.83 | NISCH (0.52) | NISCHMAOAMAOBADRA1DADRA1A | |
| SCHEMBL7861399 | 0.82 | ADRA2A (0.47) | NISCHMAOAMAOBAOC3ADRA2A | |
| SCHEMBL7854564 | 0.82 | ADRA2A (0.47) | NISCHMAOAMAOBAOC3ADRA2A | |
| SCHEMBL9440635 | 0.80 | NISCH (0.51) | NISCHMAOAMAOBADRA1DADRA1A | |
| SCHEMBL9440611 | 0.79 | NISCH (0.50) | NISCHMAOAMAOBADRA1DADRA1A | |
| SCHEMBL9445174 | 0.75 | NISCH (0.55) | NISCHMAOAMAOBADRA1DADRA1A | |
| SCHEMBL3169171 | 0.74 | NISCH (0.52) | NISCHMAOAMAOBHTR1AADRA2A | |
| SCHEMBL9440279 | 0.73 | NISCH (0.57) | NISCHMAOAMAOBADRA1DADRA1A | |
| SCHEMBL7854360 | 0.72 | MAOA (0.47) | NISCHMAOAMAOBADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625969-A1 | ARYLALKOXYPHENOXY-IMIDAZOLINE COMPOUNDS | MERRELL PHARMACEUTICALS INC. (US) | 1994-11-30 | — | — | EP | claimed |