Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 5/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9440912 | 0.84 | TSHR (0.49) | S1PR1S1PR3TSHRSMN1; SMN2KDM4E | |
| SCHEMBL9441095 | 0.84 | RXRA (0.41) | S1PR1S1PR3TSHRLTA4HKDM4E | |
| SCHEMBL9441026 | 0.80 | TSHR (0.58) | S1PR1S1PR3TSHRKDM4EFOLH1 | |
| SCHEMBL10435551 | 0.79 | TSHR (0.44) | S1PR1S1PR3TSHRLTA4HSMN1; SMN2 | |
| SCHEMBL3180487 | 0.79 | NPC1 (0.45) | S1PR1S1PR3TSHRSMN1; SMN2KDM4E | |
| SCHEMBL9440823 | 0.78 | MEN1 (0.59) | S1PR1S1PR3SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL9441029 | 0.78 | S1PR1 (0.40) | S1PR1S1PR3TSHRLTA4HKDM4E | |
| SCHEMBL9459783 | 0.77 | KDM4E (0.50) | S1PR1S1PR3TSHRSMN1; SMN2KDM4E | |
| SCHEMBL4333153 | 0.75 | TSHR (0.46) | S1PR1S1PR3TSHRSMN1; SMN2KDM4E | |
| SCHEMBL9441057 | 0.74 | ALDH1A1 (0.48) | KDM4EALDH1A1KMT2APOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371098-A | Use of oxazole compounds to treat osteoporosis | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-12-06 | — | — | US | disclosed |
| US-5239080-A | Oxazole compounds and their use as antidiabetic and bone-reduction inhibitory agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-08-24 | — | — | US | disclosed |
| EP-0440183-A1 | Oxazole compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-08-07 | — | — | EP | disclosed |