SCHEMBL4333153

SCHEMBL4333153

CCOC(=O)CCCCCc1nc(-c2ccc(Cl)cc2)co1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.46
RAB9A P51151 3/20 0.46
NPC1 O15118 2/20 0.46
LMNA P02545 2/20 0.46
POLB P06746 2/20 0.46
ALDH1A1 P00352 3/20 0.42
MAPK1 P28482 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
MAPT P10636 1/20 0.42
HDAC2 Q92769 2/20 0.42
HDAC1 Q13547 1/20 0.42
FAAH O00519 1/20 0.41
HSD17B10 Q99714 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
CYP4F2 P78329 1/20 0.41
CYP4A11 Q02928 1/20 0.41
ALPL P05186 1/20 0.40
TARBP2 Q15633 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9440912 0.91 TSHR (0.49) TSHRRAB9ANPC1LMNAPOLB
SCHEMBL4343281 0.89 FAAH (0.53) RAB9ANPC1LMNAPOLBALDH1A1
SCHEMBL4329577 0.88 ENPP3 (0.46) RAB9ANPC1POLBALDH1A1MAPT
SCHEMBL4329816 0.83 DAGLA (0.47) TSHRALDH1A1MAPTHDAC2HDAC1
SCHEMBL4322293 0.80 HDAC1 (0.64) HDAC2HDAC1HDAC8
SCHEMBL9441048 0.79 SIRT2 (0.63) RAB9ANPC1LMNAPOLBALDH1A1
SCHEMBL9440975 0.78 PARP1 (0.48) LMNAPOLBALDH1A1MAPK1SMN1; SMN2
SCHEMBL3042129 0.78 CYP4F2 (0.44) POLBALDH1A1MEN1KMT2AMAPT
SCHEMBL3048357 0.76 DAGLA (0.54) MAPTHDAC2HDAC1FAAHHDAC8
SCHEMBL13361917 0.76 CYP4F2 (0.43) POLBALDH1A1MEN1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7521563-B2 Hydroxamic acid derivative and medicine containing the same as active ingredient SHIZUOKA COFFEIN CO., LTD. (JP) 2009-04-21 US disclosed
US-20070208065-A1 Hydroxamic Acid Derivative and Medicine Containing the Same as Active Ingredient SHIZUOKA COFFEIN CO., LTD. (JP) 2007-09-06 US disclosed
EP-1787986-A1 HYDROXAMIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME AS ACTIVE INGREDIENT SHIZUOKA COFFEIN CO., LTD. (JP) 2007-05-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070208065-A1 Hydroxamic Acid Derivative and Medicine Containing the Same as Active Ingredient IL6, IL1A, TNF TSHR 3373/4885RAB9A 4443/4885NPC1 4407/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.