Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | GRM5 | P41594 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL944788 | 0.72 | PLK4 (0.47) | RAB9ANPC1KDM4EALDH1A1HPGD | |
| SCHEMBL31605561 | 0.72 | LMNA (0.43) | RAB9AKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL28522895 | 0.69 | MEN1 (0.40) | RAB9ANPC1KMT2AKDM4EMEN1 | |
| SCHEMBL4243217 | 0.65 | BCAT2 (1.00) | BCAT2RAB9ANPC1KMT2AKDM4E | |
| SCHEMBL27810327 | 0.65 | EGLN1 (0.58) | RAB9ANPC1KMT2AKDM4EMEN1 | |
| SCHEMBL21639618 | 0.64 | LCK (0.41) | BCAT2RAB9ANPC1KDM4ELCK | |
| SCHEMBL29843226 | 0.63 | MAPK1 (0.54) | RAB9ANPC1KMT2AKDM4EALDH1A1 | |
| SCHEMBL10680062 | 0.63 | JAK2 (0.51) | BCAT2GRM5CYP11B2CSF1R | |
| SCHEMBL5535329 | 0.63 | MAPK14 (0.35) | MAPK14 | |
| SCHEMBL10367732 | 0.63 | KDM4E (0.39) | KMT2AKDM4EMEN1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872128-B2 | Benzisoxazole and isoxazolo-pyridine compounds and method of use | AMGEN INC. (US) | 2011-01-18 | — | — | US | disclosed |
| US-20080227779-A1 | Heterocyclic compounds and methods of use | AMGEN INC. (US) | 2008-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080227779-A1 | Heterocyclic compounds and methods of use | KIT, TPSG1, CMA1 | BCAT2 2437/4885RAB9A 1025/4885NPC1 3076/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.