Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BCL2 | P10415 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9443440 | 0.87 | KCNE1 (0.35) | SMN1; SMN2ALDH1A1KMT2ALMNAHTT | |
| SCHEMBL9735702 | 0.86 | PBRM1 (0.31) | PBRM1BACE1IDO1 | |
| SCHEMBL9443653 | 0.85 | TDP1 (0.35) | SMN1; SMN2ALDH1A1LMNAHTTTSHR | |
| SCHEMBL9443581 | 0.85 | CA12 (0.38) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL9443541 | 0.85 | AKR1B1 (0.32) | — | |
| SCHEMBL9443561 | 0.84 | ABCC9 (0.42) | LMNA | |
| SCHEMBL9443605 | 0.84 | HTR1A (0.36) | SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL9443460 | 0.84 | AKR1B1 (0.35) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL9443570 | 0.84 | ABCC9 (0.42) | LMNA | |
| SCHEMBL9443552 | 0.84 | ABCC9 (0.42) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5232944-A | Hypotensive agents | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-08-03 | — | — | US | disclosed |
| EP-0422450-A2 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-04-17 | — | — | EP | disclosed |