Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9443603 | 0.86 | PBRM1 (0.34) | PBRM1BACE1IDO1 | |
| SCHEMBL9735212 | 0.85 | CA12 (0.34) | IDO1 | |
| SCHEMBL9735693 | 0.85 | ABCC9 (0.39) | — | |
| SCHEMBL9737027 | 0.85 | AKR1B1 (0.34) | — | |
| SCHEMBL9736148 | 0.81 | XIAP (0.32) | PBRM1IDO1 | |
| SCHEMBL9735711 | 0.79 | ALDH1A1 (0.31) | — | |
| SCHEMBL9735552 | 0.78 | IDO1 (0.32) | IDO1 | |
| SCHEMBL9735545 | 0.78 | — | — | |
| SCHEMBL9737313 | 0.77 | PKM (0.31) | BACE1 | |
| SCHEMBL9845071 | 0.74 | XIAP (0.33) | IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |
| EP-0415065-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |