Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylthiouracil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPO known ✓ | P07202 | 1/20 | 0.69 |
| ▸ | LPO | P22079 | 2/20 | 0.69 |
| ▸ | MPO | P05164 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.37 |
| ▸ | CYB5R3 | P00387 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1691795 | 0.85 | KMT2A (0.55) | LPOMPOTPOTSHRCYP2C19 | |
| Propylthiouracil SCHEMBL41239 | 0.83 | LPO (1.00) | LPOMPOTPOTSHRCYP2C19 | |
| Propylthiouracil SCHEMBL5493716 | 0.83 | LPO (1.00) | LPOMPOTPOTSHRCYP2C19 | |
| Propylthiouracil SCHEMBL27995248 | 0.82 | LPO (0.96) | LPOMPOTPOTSHRCYP2C19 | |
| Propylthiouracil SCHEMBL13723721 | 0.76 | LPO (0.83) | LPOMPOTPOTSHRCYP2C19 | |
| SCHEMBL10983716 | 0.76 | KMT2A (0.53) | LPOMPOTPOTSHRCYP2C19 | |
| SCHEMBL11343851 | 0.74 | KMT2A (0.51) | KMT2ATDP1FFAR3HCAR2GPR84 | |
| SCHEMBL8407853 | 0.74 | KMT2A (0.90) | LPOMPOTPOTSHRCYP2C19 | |
| SCHEMBL10735494 | 0.73 | KMT2A (0.50) | KMT2ATDP1FFAR3HCAR2GPR84 | |
| SCHEMBL3540299 | 0.73 | KMT2A (0.60) | KMT2ATDP1FFAR3HCAR2FFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0504279-A4 | FERMENTATION PROCESS FOR THE PRODUCTION OF PYRIMIDINE DEOXYRIBONUCLEOSIDES | — | 1993-02-17 | — | — | EP | disclosed |
| EP-0504279-A1 | FERMENTATION PROCESS FOR THE PRODUCTION OF PYRIMIDINE DEOXYRIBONUCLEOSIDES. | CHEMGEN CORP (US) | 1992-09-23 | — | — | EP | disclosed |
| WO-1991009130-A1 | FERMENTATION PROCESS FOR THE PRODUCTION OF PYRIMIDINE DEOXYRIBONUCLEOSIDES | CHEMGEN CORPORATION (US) | 1991-06-27 | — | — | WO | disclosed |