Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.63 |
| ▸ | JUN | P05412 | 1/20 | 0.63 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.63 |
| ▸ | CA1 | P00915 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.61 |
| ▸ | CA4 | P22748 | 1/20 | 0.61 |
| ▸ | BCHE | P06276 | 1/20 | 0.56 |
| ▸ | GUSB | P08236 | 1/20 | 0.56 |
| ▸ | PELI1 | Q96FA3 | 3/20 | 0.55 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1562801 | 1.00 | MAPT (0.65) | MAPTLMNANFKB1JUNNFE2L2 | |
| SCHEMBL17305570 | 1.00 | MAPT (0.65) | MAPTLMNANFKB1JUNNFE2L2 | |
| SCHEMBL14244199 | 0.83 | HDAC8 (0.66) | MAPTLMNANFKB1JUNNFE2L2 | |
| SCHEMBL12426301 | 0.83 | HDAC8 (0.66) | MAPTLMNANFKB1JUNNFE2L2 | |
| SCHEMBL17151526 | 0.81 | MMP1 (0.46) | MAPTLMNAPELI1KDM4ENPC1 | |
| SCHEMBL12425714 | 0.81 | NFKB1 (0.63) | MAPTLMNANFKB1JUNNFE2L2 | |
| SCHEMBL29412622 | 0.81 | NFKB1 (0.63) | MAPTLMNANFKB1JUNNFE2L2 | |
| SCHEMBL4254014 | 0.81 | NFKB1 (0.63) | MAPTLMNANFKB1JUNNFE2L2 | |
| Leucine SCHEMBL10491460 | 0.81 | NFKB1 (0.46) | MAPTLMNANFKB1JUNNFE2L2 | |
| SCHEMBL18310156 | 0.81 | EGFR (0.63) | MAPTLMNANFKB1JUNNFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5273999-A | A 4-keto-boroalkyleneoxychroman or 2,3-dihydrobenzofuran derivative | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |