Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9447030 | 0.88 | OPRM1 (0.36) | L3MBTL1MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL9447192 | 0.76 | OPRM1 (0.43) | TSHROPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL9447077 | 0.74 | OPRM1 (0.49) | TSHROPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL7951502 | 0.74 | CYP2D6 (0.52) | MEN1KMT2AALDH1A1OPRM1OPRD1 | |
| SCHEMBL27972359 | 0.74 | CYP2D6 (0.52) | MEN1KMT2AALDH1A1OPRM1OPRD1 | |
| SCHEMBL11830842 | 0.70 | LMNA (0.36) | MEN1KMT2AALDH1A1TSHROPRM1 | |
| SCHEMBL28033232 | 0.70 | RCE1 (0.35) | ALDH1A1TSHRHTT | |
| SCHEMBL28047160 | 0.70 | OPRM1 (0.53) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL11193610 | 0.69 | CYP2D6 (0.38) | ALDH1A1TSHROPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL28274952 | 0.69 | OPRM1 (0.52) | MEN1KMT2AOPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250286-A | Treatment of chronic obstructive pulmonary disease (COPD) by inhalation of an imidazoline | AEGIS TECHNOLOGY, INC. (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0527925-A4 | TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) BY INHALATION OF AN IMIDAZOLINE | — | 1993-09-15 | — | — | EP | disclosed |
| EP-0527925-A1 | TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) BY INHALATION OF AN IMIDAZOLINE | AEGIS TECHNOLOGIE, INC. (US) | 1993-02-24 | — | — | EP | disclosed |
| US-5096916-A | Administering tolazoline | AEGIS TECHNOLOGY, INC. (US) | 1992-03-17 | — | — | US | disclosed |
| WO-1991016891-A1 | TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) BY INHALATION OF AN IMIDAZOLINE | AEGIS TECHNOLOGY, INC. (US) | 1991-11-14 | — | — | WO | disclosed |