Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29696988 | 0.79 | MAPT (0.37) | SMN1; SMN2MAPTKDM4EPKMTDP1 | |
| SCHEMBL4645762 | 0.76 | MAPT (0.36) | SMN1; SMN2MAPTKDM4EPKMTDP1 | |
| SCHEMBL10104754 | 0.75 | ALDH1A1 (0.44) | SMN1; SMN2MAPTKDM4EPKMTDP1 | |
| SCHEMBL19407746 | 0.73 | HDAC3 (0.48) | MAPTKDM4ETDP1HDAC3HDAC4 | |
| SCHEMBL11064216 | 0.72 | ALOX15 (0.42) | MAPTPKMALDH1A1MEN1GAA | |
| SCHEMBL19622316 | 0.72 | ALOX15 (0.38) | MAPTTDP1CYP1A2ALDH1A1MEN1 | |
| SCHEMBL12565531 | 0.72 | ALDH1A1 (0.45) | SMN1; SMN2MAPTKDM4ETDP1CYP1A2 | |
| SCHEMBL11578003 | 0.68 | MAPT (0.50) | SMN1; SMN2MAPTKDM4EPKMTDP1 | |
| SCHEMBL3440680 | 0.68 | SMN1; SMN2 (0.42) | SMN1; SMN2MAPTPKML3MBTL1ALDH1A1 | |
| SCHEMBL3440574 | 0.68 | L3MBTL1 (0.38) | SMN1; SMN2MAPTKDM4EPKMHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5190971-A | SUBSTITUTED DIBENZ-OXA-THIOCINONES, -12-OXIDES AND -12,12-DIOXIDES, A PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICAMENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1993-03-02 | — | — | US | disclosed |
| EP-0490219-A1 | Substituted dibenz-oxo-thiocinones, -12-oxides and -12,12-dioxides; method for their preparation and their use in medicaments | BAYER AG (DE) | 1992-06-17 | — | — | EP | disclosed |