Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 3/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | S100A4 | P26447 | 3/20 | 0.34 |
| ▸ | BLM | P54132 | 2/20 | 0.34 |
| ▸ | BCHE | P06276 | 2/20 | 0.34 |
| ▸ | CES1 | P23141 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | TERT | O14746 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL65679 | 0.69 | MAOB (0.42) | KDM4EALDH1A1HPGDMAOAMAOB | |
| SCHEMBL5281409 | 0.66 | — | — | |
| SCHEMBL31218602 | 0.66 | MAOA (0.60) | KDM4EALDH1A1HPGDMAOAMAOB | |
| SCHEMBL7380169 | 0.66 | MAOA (0.60) | KDM4EALDH1A1HPGDMAOAMAOB | |
| SCHEMBL2929432 | 0.65 | PKM (0.52) | KDM4EALDH1A1HPGDMAOAMAOB | |
| SCHEMBL1913191 | 0.64 | BRD4 (0.47) | ALDH1A1MAOAMEN1KMT2ABCHE | |
| SCHEMBL10556518 | 0.64 | MAOA (0.53) | KDM4EALDH1A1HPGDMAOAMAOB | |
| SCHEMBL855431 | 0.61 | MAOA (0.56) | KDM4EMAOAMAOBMEN1KMT2A | |
| SCHEMBL19537629 | 0.61 | ALDH1A1 (0.48) | KDM4EALDH1A1HPGDMAOAMEN1 | |
| SCHEMBL88188 | 0.61 | CES1 (0.52) | KDM4EALDH1A1HPGDMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0490219-A1 | Substituted dibenz-oxo-thiocinones, -12-oxides and -12,12-dioxides; method for their preparation and their use in medicaments | BAYER AG (DE) | 1992-06-17 | — | — | EP | claimed |
| US-5190971-A | SUBSTITUTED DIBENZ-OXA-THIOCINONES, -12-OXIDES AND -12,12-DIOXIDES, A PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICAMENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1993-03-02 | — | — | US | disclosed |
| EP-0490219-A1 | Substituted dibenz-oxo-thiocinones, -12-oxides and -12,12-dioxides; method for their preparation and their use in medicaments | BAYER AG (DE) | 1992-06-17 | — | — | EP | disclosed |
| EP-0490219-A1 | Substituted dibenz-oxo-thiocinones, -12-oxides and -12,12-dioxides; method for their preparation and their use in medicaments | BAYER AG (DE) | 1992-06-17 | — | — | EP | disclosed |