Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
| ▸ | FNTB | P49356 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9282351 | 0.79 | ACHE (0.59) | ACHEERN1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL2621002 | 0.78 | ERN1 (0.50) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL10064029 | 0.78 | ACHE (0.61) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL9596755 | 0.78 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL13937932 | 0.77 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL12954538 | 0.77 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL15679419 | 0.77 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL15725791 | 0.77 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL10130968 | 0.73 | AMY1A (0.47) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL20109779 | 0.73 | ACHE (0.53) | PDE4APDE4BPDE4CPDE4DACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5190971-A | SUBSTITUTED DIBENZ-OXA-THIOCINONES, -12-OXIDES AND -12,12-DIOXIDES, A PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICAMENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1993-03-02 | — | — | US | disclosed |
| EP-0490219-A1 | Substituted dibenz-oxo-thiocinones, -12-oxides and -12,12-dioxides; method for their preparation and their use in medicaments | BAYER AG (DE) | 1992-06-17 | — | — | EP | disclosed |