Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10753396 | 0.83 | — | — | |
| SCHEMBL610655 | 0.81 | KDM4E (0.51) | KDM4E | |
| SCHEMBL1669168 | 0.81 | KDM4E (0.46) | KDM4EMEN1MAPTKMT2AMAPK1 | |
| SCHEMBL9448394 | 0.78 | KDM4E (0.37) | KDM4EMEN1MAPTKMT2AATM | |
| SCHEMBL2778058 | 0.77 | ALDH1A1 (0.40) | KDM4EMEN1MAPTKMT2AMAPK1 | |
| SCHEMBL10835651 | 0.76 | KDM4E (0.38) | KDM4EMEN1MAPTKMT2AATM | |
| SCHEMBL10749319 | 0.76 | DRD2 (0.36) | — | |
| SCHEMBL9448055 | 0.75 | SIGMAR1 (0.41) | KDM4EMAPTLMNAPOLB | |
| SCHEMBL9448099 | 0.75 | KDM4E (0.35) | KDM4EATMPOLBTDP1MAPK1 | |
| SCHEMBL5011572 | 0.74 | KDM4E (0.43) | KDM4EMEN1MAPTKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5248677-A | Nervous system disorders or antidepressants | ABBOTT LABORATORIES (US) | 1993-09-28 | — | — | US | disclosed |
| US-5180733-A | Antidepressants or nervous systen disorders | ABBOTT LABORATORIES (US) | 1993-01-19 | — | — | US | disclosed |
| EP-0461353-A1 | Biogenic amine uptake inhibitors | ABBOTT LABORATORIES (US) | 1991-12-18 | — | — | EP | disclosed |