Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9449066 | 0.85 | CYP1A2 (0.40) | OPRM1OPRK1OPRD1OPRL1MCHR1 | |
| SCHEMBL9448889 | 0.85 | SLC6A4 (0.46) | OPRM1OPRK1OPRD1OPRL1MCHR1 | |
| SCHEMBL9448929 | 0.82 | KDM4E (0.41) | OPRM1OPRK1OPRD1OPRL1MCHR1 | |
| SCHEMBL9448767 | 0.82 | MCHR1 (0.50) | MCHR1HTR6MEN1ALDH1A1KMT2A | |
| SCHEMBL9448855 | 0.82 | CHRNA7 (0.49) | MCHR1HTR2AKCNH2HTR2C | |
| SCHEMBL9448816 | 0.81 | MCHR1 (0.51) | MCHR1MEN1KMT2AKCNH2HTR3A | |
| SCHEMBL9448822 | 0.80 | KDM4E (0.47) | MCHR1MEN1ALDH1A1POLBKMT2A | |
| SCHEMBL9449116 | 0.79 | KMT2A (0.41) | MCHR1ALDH1A1KMT2AHTR3A | |
| SCHEMBL9449189 | 0.79 | MCHR1 (0.40) | MCHR1HTR6ALDH1A1HTR7HTR2C | |
| SCHEMBL9448852 | 0.78 | ALDH1A1 (0.40) | ALDH1A1POLBADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5227386-A | INDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-07-13 | — | — | US | disclosed |