Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.47 |
| ▸ | TUBB | P07437 | 2/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.47 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.47 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.47 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.47 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.47 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.47 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.47 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.47 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29198788 | 0.73 | KDM4E (0.66) | HTR6KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL3029129 | 0.72 | HTR6 (0.75) | HTR6TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL27408415 | 0.72 | ALDH1A1 (0.54) | HTR6TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8977641 | 0.72 | ALDH1A1 (0.50) | HTR6TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL9449759 | 0.72 | GPR17 (0.54) | HTR6TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL28987827 | 0.72 | HTR6 (0.46) | HTR6TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL15623026 | 0.72 | HTR6 (0.52) | HTR6TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7245267 | 0.72 | HTR6 (0.46) | HTR6TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL9189433 | 0.71 | ALDH1A1 (0.65) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7511884 | 0.71 | DRD2 (0.61) | HTR6DRD2DRD4DRD3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229413-A | Nervous system disorders | G. D. SEARLE & CO. (US) | 1993-07-20 | — | — | US | disclosed |
| US-5137910-A | Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders | C.D. SEARLE & CO. (US) | 1992-08-11 | — | — | US | disclosed |
| EP-0396124-A2 | Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders | G.D. Searle & Co. (US) | 1990-11-07 | — | — | EP | disclosed |