Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2317153 | 0.86 | TDP1 (0.51) | TDP1TSHRCYP2C19KMT2APTGDR2 | |
| SCHEMBL6718467 | 0.84 | L3MBTL1 (0.50) | TDP1TSHRKMT2APTGDR2MAPT | |
| SCHEMBL9449849 | 0.82 | LMNA (0.55) | TDP1TSHRKMT2APTGDR2MAPT | |
| SCHEMBL9449949 | 0.80 | ALDH1A1 (0.46) | TDP1TSHRKMT2AL3MBTL1KDM4E | |
| SCHEMBL3931134 | 0.79 | PKM (0.45) | TDP1PTGDR2POLBSMN1; SMN2GLA | |
| SCHEMBL5619089 | 0.79 | KDM4E (0.44) | TDP1CYP2C19KMT2APTGDR2POLB | |
| SCHEMBL5503687 | 0.79 | PKM (0.53) | TDP1TSHRPTGDR2POLBSMN1; SMN2 | |
| SCHEMBL7380176 | 0.78 | POLB (0.62) | TDP1TSHRKMT2APTGDR2POLB | |
| SCHEMBL3209384 | 0.78 | POLB (0.62) | TDP1TSHRKMT2APTGDR2POLB | |
| SCHEMBL5460045 | 0.77 | L3MBTL1 (0.65) | TDP1TSHRKMT2APTGDR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5232978-A | 1-(2-arylethyl)-pyrrolidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-08-03 | — | — | US | disclosed |
| EP-0483580-A2 | 1-(2-Arylethyl)-pyrrolidine | MERCK PATENT GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |
| EP-0374756-A2 | Nitrogen-containing cyclic compounds | MERCK PATENT GmbH (DE) | 1990-06-27 | — | — | EP | disclosed |