Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | DRD1 | P21728 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | PDE9A | O76083 | 1/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9682075 | 0.90 | OPRM1 (0.41) | SLC6A3CHRM2ADRA2ACHRM1DRD1 | |
| SCHEMBL9450757 | 0.79 | SLC6A4 (0.45) | SLC6A2HTR1ASLC6A3SLC6A4CHRM2 | |
| SCHEMBL6966240 | 0.77 | HSP90AA1 (0.36) | SLC6A3CHRM2ADRA2ACHRM1DRD1 | |
| SCHEMBL6954699 | 0.77 | CHRM2 (0.35) | SLC6A2HTR1ASLC6A3SLC6A4CHRM2 | |
| SCHEMBL6970505 | 0.76 | CYP2C19 (0.39) | SLC6A2HTR1ASLC6A3SLC6A4CHRM2 | |
| SCHEMBL6969377 | 0.75 | OPRM1 (0.37) | SLC6A2HTR1ASLC6A3SLC6A4CHRM2 | |
| SCHEMBL1769006 | 0.73 | SLC6A3 (0.46) | SLC6A2SLC6A3SLC6A4CHRM2ADRA2A | |
| SCHEMBL10808078 | 0.73 | OPRM1 (0.44) | SLC6A2SLC6A3CHRM2ADRA2ACHRM1 | |
| SCHEMBL6584924 | 0.73 | CHRM2 (0.49) | SLC6A2HTR1ASLC6A3SLC6A4CHRM2 | |
| SCHEMBL1740319 | 0.72 | SLC6A4 (0.47) | SLC6A2SLC6A3SLC6A4KCNH2PDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0560905-A1 | 3-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENOXY]-1-AZETIDINE CARBOXAMIDES HAVING ANTICONVULSANT ACTIVITY. | ROBINS CO INC A H (US) | 1993-09-22 | — | — | EP | disclosed |
| WO-1992010474-A1 | 3-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENOXY]-1-AZETIDINE CARBOXAMIDES HAVING ANTICONVULSANT ACTIVITY | A.H. ROBINS COMPANY, INCORPORATED (US) | 1992-06-25 | — | — | WO | disclosed |
| US-5095014-A | 3-(2-chloro-4-(trifluoromethyl)phenoxy)-1-azetidine carboxamides having anticonvulsant activity | A. H. ROBINS COMPANY, INCORPORATED (US) | 1992-03-10 | — | — | US | disclosed |