Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 4/20 | 0.46 |
| ▸ | HTR2C known ✓ | P28335 | 4/20 | 0.46 |
| ▸ | HTR2B known ✓ | P41595 | 4/20 | 0.46 |
| ▸ | DRD2 known ✓ | P14416 | 3/20 | 0.45 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.42 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.42 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.50 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9451635 | 1.00 | MCHR1 (0.50) | MCHR1CHIAHTR2AHTR2CHTR2B | |
| Fumaric Acid SCHEMBL9451571 | 0.89 | MCHR1 (0.55) | MCHR1HTR2AHTR2CHTR2BSIGMAR1 | |
| Fumaric Acid SCHEMBL9451568 | 0.89 | MCHR1 (0.55) | MCHR1HTR2AHTR2CHTR2BSIGMAR1 | |
| Fumaric Acid SCHEMBL9451537 | 0.88 | CHIA (0.49) | MCHR1CHIAHTR2AHTR2CHTR2B | |
| Fumaric Acid SCHEMBL9451533 | 0.88 | CHIA (0.49) | MCHR1CHIAHTR2AHTR2CHTR2B | |
| Fumaric Acid SCHEMBL9451712 | 0.85 | CHIA (0.45) | MCHR1CHIAHTR2AHTR2CHTR2B | |
| Fumaric Acid SCHEMBL9451709 | 0.85 | CHIA (0.45) | MCHR1CHIAHTR2AHTR2CHTR2B | |
| Fumaric Acid SCHEMBL7300329 | 0.85 | MAPT (0.53) | MCHR1CHIAHTR2AHTR2CHTR2B | |
| Fumaric Acid SCHEMBL9451626 | 0.85 | MAPT (0.53) | MCHR1CHIAHTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL7476858 | 0.80 | L3MBTL3 (0.52) | CHIALMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260318-A | Phenylpiperidylamines and drugs containing them | BASF AKTIENGESELLSCHAFT (DE) | 1993-11-09 | — | — | US | disclosed |