Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.42 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.42 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.42 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL8386859 | 0.93 | POLB (0.51) | HTR6GAAPOLBGFERTSHR | |
| SCHEMBL139251 | 0.93 | POLB (0.55) | HTR6GAAPOLBGFERTSHR | |
| SCHEMBL12903976 | 0.83 | HTR6 (0.57) | HTR6GAAPOLBGFERTSHR | |
| SCHEMBL22647140 | 0.81 | POLB (0.50) | HTR6GAAPOLBGFERTSHR | |
| SCHEMBL6313132 | 0.79 | HTR6 (0.44) | HTR6GAAPOLBGFERTSHR | |
| Formaldehyde SCHEMBL15348580 | 0.79 | HTR6 (0.48) | HTR6GAAPOLBGFERKMT2A | |
| SCHEMBL29709995 | 0.79 | POLB (0.66) | HTR6GAAPOLBGFERTSHR | |
| SCHEMBL312517 | 0.79 | POLB (0.66) | HTR6GAAPOLBGFERTSHR | |
| SCHEMBL1345089 | 0.79 | TDP1 (0.52) | GAAPOLBTSHRHTTL3MBTL1 | |
| SCHEMBL1346827 | 0.78 | POLB (0.59) | HTR6GAAPOLBGFERTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5246507-A | Hydroxystyrene polymer and metal ion | KAO CORPORATION (JP) | 1993-09-21 | — | — | US | disclosed |
| US-5188866-A | Recording coating of ferromagnetic metal and polymer; corrosion resistance | KAO CORPORATION (JP) | 1993-02-23 | — | — | US | disclosed |
| US-5080982-A | Magnetic recording medium | KAO CORPORATION (JP) | 1992-01-14 | — | — | US | disclosed |
| US-4978399-A | Plating or painting pretreatment with an ionized metal compound and a hydroxystyrenesulfonate polymer; coroosion resistance; adhesion | KAO CORPORATION (JP) | 1990-12-18 | — | — | US | disclosed |