Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.35 |
| ▸ | TDO2 | P48775 | 3/20 | 0.35 |
| ▸ | ACP3 | P15309 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7868180 | 0.82 | — | — | |
| SCHEMBL27854887 | 0.80 | TRPA1 (0.42) | IDO1TDO2POLBLMNA | |
| SCHEMBL11075712 | 0.80 | TRPA1 (0.42) | IDO1TDO2POLBLMNA | |
| SCHEMBL7868183 | 0.79 | SLC6A2 (0.35) | IDO1TDO2ACP3SRC | |
| SCHEMBL11088217 | 0.75 | IDO1 (0.35) | IDO1TDO2CYP2D6SRCKMT2A | |
| SCHEMBL7442974 | 0.73 | MIF (0.35) | CYP2D6KMT2ALMNA | |
| SCHEMBL7704413 | 0.72 | KMT2A (0.42) | ACP3CYP2D6SRCEPHX1KMT2A | |
| SCHEMBL11176872 | 0.72 | CYP2D6 (0.34) | CYP2D6SRCKMT2ALMNAMAPK1 | |
| SCHEMBL7306869 | 0.72 | KMT2A (0.42) | ACP3CYP2D6SRCEPHX1KMT2A | |
| SCHEMBL2840417 | 0.72 | IDO1 (0.38) | IDO1TDO2ACP3CYP2D6SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989446-B2 | 4-amino 5-cyanopyrimidine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2011-08-02 | — | — | US | disclosed |
| US-20110009620-A1 | 4-Amino-5-cyanopyrimidine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. | 2011-01-13 | — | — | US | disclosed |
| US-7834002-B2 | 4-amino-5-cyanopyrimidine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2010-11-16 | — | — | US | disclosed |
| US-20080182854-A1 | 4-Amino-5-Cyanopyrimidine Derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-07-31 | — | — | US | disclosed |
| EP-1740574-B1 | 4-AMINO-5-CYANOPYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2007-06-27 | — | — | EP | disclosed |
| EP-1740574-A2 | 4-AMINO-5-CYANOPYRIMIDINE DERIVATIVES | Otsuka Pharmaceutical Company, Limited (JP) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005105778-A2 | 4-AMINO-5-CYANOPYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-11-10 | — | — | WO | disclosed |
| EP-1480647-A4 | MONO-ESTER AND ASYMMETRICALLY SUBSTITUTED DI-ESTER PRO-DRUGS OF THE DOPAMINE D1 RECEPTOR AGONISTS | DARPHARMA INC (US) | 2005-07-13 | — | — | EP | disclosed |
| EP-1480647-A1 | MONO-ESTER AND ASYMMETRICALLY SUBSTITUTED DI-ESTER PRO-DRUGS OF THE DOPAMINE D1 RECEPTOR AGONISTS | Darpharma, INC. (US) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003070245-A1 | MONO-ESTER AND ASYMMETRICALLY SUBSTITUTED DI-ESTER PRO-DRUGS OF THE DOPAMINE D1 RECEPTOR AGONISTS | DARPHARMA, INC. (US) | 2003-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009620-A1 | 4-Amino-5-cyanopyrimidine derivatives | ADORA2A, ADORA1, ADORA3 | IDO1 1380/4885TDO2 2707/4885ACP3 4020/4885 |
| US-20080182854-A1 | 4-Amino-5-Cyanopyrimidine Derivatives | ADORA2A, ADORA1, ADORA3 | IDO1 1380/4885TDO2 2707/4885ACP3 4020/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.