Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8139004 | 0.77 | ALDH1A1 (0.44) | — | |
| SCHEMBL3908655 | 0.77 | HTR5A (0.39) | HTR5ADRD2DRD3LMNASMN1; SMN2 | |
| SCHEMBL9358367 | 0.77 | HTR5A (0.44) | HTR5ADRD2DRD3LMNASMN1; SMN2 | |
| SCHEMBL26889686 | 0.74 | HTR5A (0.42) | HTR5ADRD2DRD3ADRA2A | |
| SCHEMBL23023377 | 0.72 | HTR5A (0.46) | HTR5ADRD2DRD3LMNASMN1; SMN2 | |
| SCHEMBL13999138 | 0.71 | DRD2 (0.49) | HTR5ADRD2DRD3ADRA2A | |
| SCHEMBL29823229 | 0.71 | DRD2 (0.49) | HTR5ADRD2DRD3ADRA2A | |
| SCHEMBL17014343 | 0.70 | HTR5A (0.47) | HTR5ADRD2DRD3MEN1KMT2A | |
| SCHEMBL13647144 | 0.70 | IDO1 (0.41) | HTR5ADRD2DRD3LMNASMN1; SMN2 | |
| SCHEMBL29598562 | 0.69 | KDM1A (0.46) | DRD2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5244888-A | Hexahydroindenopyrroles and hexahydrobenzisoindoles | ABBOTT LABORATORIES (US) | 1993-09-14 | — | — | US | disclosed |
| US-5049564-A | Hypotensive, 5-hydroxytryptamine | ABBOTT LABORATORIES (US) | 1991-09-17 | — | — | US | disclosed |
| EP-0422134-A1 | 5-HT SELECTIVE AGENTS. | ABBOTT LAB (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1990006927-A1 | 5-HT SELECTIVE AGENTS | ABBOTT LABORATORIES (US) | 1990-06-28 | — | — | WO | disclosed |