Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | PAK4 | O96013 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9152953 | 1.00 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9280526 | 0.99 | RAB9A (0.54) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL9459226 | 0.86 | XDH (0.53) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL9251328 | 0.86 | XDH (0.53) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL9458934 | 0.82 | RAB9A (0.54) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL9251283 | 0.82 | RAB9A (0.54) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL909245 | 0.82 | RAB9A (0.47) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL719522 | 0.82 | RAB9A (0.47) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL9151158 | 0.82 | RAB9A (0.46) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL9150467 | 0.82 | RAB9A (0.52) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5180831-A | Acetylcholinesterase Inhibitors | GEORGIA TECH RESEARCH CORPORATION (US) | 1993-01-19 | — | — | US | disclosed |