Hydrochloric Acid

Hydrochloric Acid

SCHEMBL9251328

C[n+]1cccc(O)c1C=NNC(=S)Nc1ccccc1.[Cl-]

nearest known ligand 0.53

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
XDH P47989 1/20 0.53
NPC1 O15118 6/20 0.49
RAB9A P51151 6/20 0.49
SMN1; SMN2 Q16637 6/20 0.49
NPSR1 Q6W5P4 4/20 0.49
KMT2A Q03164 4/20 0.49
L3MBTL1 Q9Y468 4/20 0.49
LMNA P02545 3/20 0.49
MEN1 O00255 2/20 0.49
GAA P10253 2/20 0.49
ALDH1A1 P00352 5/20 0.46
KDM4E B2RXH2 5/20 0.46
HPGD P15428 2/20 0.46
DUSP3 P51452 1/20 0.46
PTPN5 P54829 1/20 0.46
PTPN11 Q06124 1/20 0.46
RECQL P46063 3/20 0.45
POLB P06746 2/20 0.45
HTT P42858 2/20 0.45
BCHE P06276 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9459226 1.00 XDH (0.53) XDHNPC1RAB9ASMN1; SMN2NPSR1
Hydrochloric Acid SCHEMBL9152953 0.86 RAB9A (0.53) NPC1RAB9ASMN1; SMN2NPSR1KMT2A
Hydrochloric Acid SCHEMBL9459288 0.86 RAB9A (0.53) NPC1RAB9ASMN1; SMN2NPSR1KMT2A
SCHEMBL9280526 0.85 RAB9A (0.54) NPC1RAB9ASMN1; SMN2NPSR1KMT2A
Hydrochloric Acid SCHEMBL9287079 0.83 NPC1 (0.50) XDHNPC1RAB9ASMN1; SMN2NPSR1
Hydrochloric Acid SCHEMBL9287072 0.83 NPC1 (0.50) XDHNPC1RAB9ASMN1; SMN2NPSR1
Hydrochloric Acid SCHEMBL9459502 0.81 XDH (0.52) XDHNPC1RAB9ASMN1; SMN2NPSR1
Hydrochloric Acid SCHEMBL9248819 0.81 XDH (0.52) XDHNPC1RAB9ASMN1; SMN2NPSR1
Hydrochloric Acid SCHEMBL9149882 0.81 TOP2A (0.51) NPC1RAB9ASMN1; SMN2NPSR1KMT2A
Hydrochloric Acid SCHEMBL9153136 0.80 KDM4E (0.54) SMN1; SMN2L3MBTL1LMNAGAAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1995021822-A1 PYRIDINIUM COMPOUNDS GEORGIA TECH RESEARCH CORPORATION (US) 1995-08-17 WO disclosed
EP-0643697-A4 QUATERNARY PYRIDINIUM COMPOUNDS. 1995-04-12 EP disclosed
EP-0643697-A1 QUATERNARY PYRIDINIUM COMPOUNDS GEORGIA TECH RESEARCH CORPORATION (US) 1995-03-22 EP disclosed
US-5290942-A Acetylcholinesterase inhibitors GEORGIA TECH RESEARCH CORPORATION (US) 1994-03-01 US disclosed
WO-1993024459-A1 QUATERNARY PYRIDINIUM COMPOUNDS GEORGIA TECH RESEARCH CORPORATION (US) 1993-12-09 WO disclosed
US-5206371-A Acetylcholinesterase inhibitor GEORGIA TECH RESEARCH CORPORATION (US) 1993-04-27 US disclosed
US-5180831-A Acetylcholinesterase Inhibitors GEORGIA TECH RESEARCH CORPORATION (US) 1993-01-19 US disclosed