Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | BHMT | Q93088 | 4/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 4/20 | 0.36 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4953418 | 0.89 | TSHR (0.48) | TSHRBHMTNOS2NOS3NOS1 | |
| SCHEMBL15948621 | 0.80 | METAP2 (0.46) | TSHRMETAP2METAP1TDP1 | |
| SCHEMBL16123404 | 0.77 | METAP2 (0.38) | TSHRMETAP2METAP1 | |
| SCHEMBL721101 | 0.77 | GPR84 (0.50) | TSHRBHMTMETAP2BHMT2METAP1 | |
| SCHEMBL9463332 | 0.77 | RNPEP (0.56) | RNPEP | |
| SCHEMBL9392724 | 0.75 | CHRM1 (0.41) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Ethionine SCHEMBL15005828 | 0.75 | BHMT (0.59) | BHMTNOS2NOS3NOS1BHMT2 | |
| Ethionine SCHEMBL31087565 | 0.75 | BHMT (0.59) | BHMTNOS2NOS3NOS1BHMT2 | |
| Ethionine SCHEMBL8967 | 0.74 | BHMT (0.63) | BHMTNOS2NOS3NOS1BHMT2 | |
| Ethionine SCHEMBL8966 | 0.74 | BHMT (0.63) | BHMTNOS2NOS3NOS1BHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5177211-A | Anti-platelet aggregation and anti-hypotensive | ALTER, S.A. (ES) | 1993-01-05 | — | — | US | disclosed |
| EP-0325187-B1 | 4-ALKYL-1, 4-DIHYDROPYRIDINES WITH PAF-ANTAGONIST ACTIVITY | ALTER, S.A. (ES) | 1992-11-11 | — | — | EP | disclosed |
| EP-0325187-A1 | 4-alkyl-1, 4-dihydropyridines with PAF-antagonist activity | ALTER, S.A. (ES) | 1989-07-26 | — | — | EP | disclosed |