Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4363943 | 0.84 | MAOB (0.57) | PTPN1SMN1; SMN2NPC1HPGDRAB9A | |
| SCHEMBL22116364 | 0.84 | PTPN1 (0.60) | PTPN1SMN1; SMN2NPC1HPGDRAB9A | |
| SCHEMBL1115032 | 0.83 | PTPN1 (0.61) | PTPN1SMN1; SMN2NPC1HPGDALDH1A1 | |
| SCHEMBL31375355 | 0.83 | APP (0.56) | FFAR1SMN1; SMN2NPC1HPGDRAB9A | |
| SCHEMBL11647126 | 0.83 | APP (0.56) | FFAR1SMN1; SMN2NPC1HPGDRAB9A | |
| SCHEMBL7291245 | 0.83 | RAB9A (0.67) | PTPN1SMN1; SMN2NPC1HPGDRAB9A | |
| SCHEMBL6630996 | 0.83 | PTGER1 (0.56) | PTPN1CYP2C9MRGPRX4 | |
| Acetic Acid SCHEMBL9467662 | 0.81 | APP (0.56) | PTPN1FFAR1SMN1; SMN2NPC1HPGD | |
| SCHEMBL16624239 | 0.81 | MAOB (0.61) | FFAR1SMN1; SMN2APPMAPTCYP2C9 | |
| SCHEMBL6324586 | 0.81 | ALDH1A1 (0.57) | PTPN1SMN1; SMN2NPC1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260294-A | Treatment of diseases caused by oxidative metabolism of arachidonic acid; antiinflammatory, antiallergins, antiarthriric | HOFFMAN-LA ROCHE INC. (US) | 1993-11-09 | — | — | US | disclosed |
| US-5132310-A | Benzochroman compounds, lipoxygenase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 1992-07-21 | — | — | US | disclosed |
| US-5015661-A | Lipoxygenase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 1991-05-14 | — | — | US | disclosed |