Phosphoric Acid

Phosphoric Acid

SCHEMBL9468960

Nc1ccc(C(=O)O)cc1O.O=P(O)(O)O

nearest known ligand 0.55

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Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP4 known ✓ P27487 1/20 0.43
KDM4E B2RXH2 6/20 0.55
GAA P10253 5/20 0.55
MAPT P10636 4/20 0.55
CA12 O43570 3/20 0.55
CA1 P00915 3/20 0.55
CA2 P00918 3/20 0.55
CA4 P22748 3/20 0.55
CA6 P23280 3/20 0.55
CA7 P43166 3/20 0.55
CA9 Q16790 3/20 0.55
CA14 Q9ULX7 3/20 0.55
POLB P06746 2/20 0.55
L3MBTL1 Q9Y468 2/20 0.55
PTGS2 P35354 1/20 0.55
CDC25B P30305 1/20 0.50
LMNA P02545 2/20 0.47
HSD17B10 Q99714 4/20 0.43
ALDH1A1 P00352 3/20 0.43
HPGD P15428 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL180385 0.92 KDM4E (0.64) KDM4EGAAMAPTCA12CA1
Hydrochloric Acid SCHEMBL9797575 0.90 MAPT (0.61) KDM4EGAAMAPTCA12CA1
SCHEMBL9306191 0.90 KDM4E (0.61) KDM4EGAAMAPTCA12CA1
Phosphoric Acid SCHEMBL9468965 0.85 KDM4E (0.55) KDM4EGAAMAPTCA12CA1
Aniline SCHEMBL7897579 0.83 KDM4E (0.53) KDM4EGAAMAPTCA12CA1
SCHEMBL10434120 0.81 MAPT (0.52) KDM4EGAAMAPTCA12CA1
SCHEMBL9328747 0.81 SRD5A2 (0.58) KDM4EGAAMAPTCA12CA1
SCHEMBL29412590 0.77 HSD17B10 (0.52) KDM4EGAAMAPTCA12CA1
SCHEMBL766129 0.77 HSD17B10 (0.52) KDM4EGAAMAPTCA12CA1
SCHEMBL2404415 0.77 HSD17B10 (0.65) KDM4ECA12CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5210171-A Process to polymerize AB-PBO monomer phosphate salts THE DOW CHEMICAL COMPANY (US) 1993-05-11 US disclosed
EP-0482072-A4 PROCESS TO SYNTHESIZE AB-PBO MONOMER AND PHOSPHATE SALTS THEREOF 1992-08-19 EP disclosed
EP-0482072-A1 PROCESS TO SYNTHESIZE AB-PBO MONOMER AND PHOSPHATE SALTS THEREOF THE DOW CHEMICAL COMPANY (US) 1992-04-29 EP disclosed
WO-1991001304-A1 PROCESS TO SYNTHESIZE AB-PBO MONOMER AND PHOSPHATE SALTS THEREOF THE DOW CHEMICAL COMPANY (US) 1991-02-07 WO disclosed