Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.53 |
| ▸ | PGR | P06401 | 6/20 | 0.51 |
| ▸ | ITGB2 | P05107 | 8/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 8/20 | 0.41 |
| ▸ | ITGAL | P20701 | 8/20 | 0.41 |
| ▸ | MARK3 | P27448 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9469711 | 0.77 | PGR (0.58) | ELANEPGRMARK3ALDH1A1 | |
| SCHEMBL3516319 | 0.74 | HSD17B10 (0.40) | ITGB2ICAM1ITGALMARK3ALDH1A1 | |
| SCHEMBL9469382 | 0.71 | PGR (0.43) | ELANEPGRMARK3ALDH1A1 | |
| SCHEMBL9470463 | 0.69 | PGR (0.46) | ELANEPGRITGB2ICAM1ITGAL | |
| SCHEMBL754868 | 0.67 | NR3C2 (0.48) | PGRCNR1ALDH1A1 | |
| SCHEMBL9469933 | 0.67 | PGR (0.60) | ELANEPGRMARK3ALDH1A1 | |
| SCHEMBL12582451 | 0.66 | EGLN1 (0.50) | — | |
| SCHEMBL9470419 | 0.66 | PGR (0.43) | ELANEPGRMARK3 | |
| SCHEMBL31180516 | 0.64 | HSD17B10 (0.39) | ALDH1A1 | |
| SCHEMBL9469726 | 0.64 | KMT2A (0.45) | ELANEPGRMARK3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5182289-A | Pyrrolo 2,3-b!Pyridin-2-one Derivatives | SCHERING CORPORATION (US) | 1993-01-26 | — | — | US | claimed |
| EP-0419561-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1991-04-03 | — | — | EP | claimed |
| WO-1989012637-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1989-12-28 | — | — | WO | claimed |
| EP-0347698-A1 | Heterobicyclic compounds having antiinflammatory activity | SCHERING CORPORATION (US) | 1989-12-27 | — | — | EP | claimed |
| US-5192800-A | Hypotensive agents | PFIZER INC. (US) | 1993-03-09 | — | — | US | disclosed |
| US-5182289-A | Pyrrolo 2,3-b!Pyridin-2-one Derivatives | SCHERING CORPORATION (US) | 1993-01-26 | — | — | US | disclosed |
| EP-0419561-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1991-04-03 | — | — | EP | disclosed |
| WO-1989012637-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1989-12-28 | — | — | WO | disclosed |
| EP-0347698-A1 | Heterobicyclic compounds having antiinflammatory activity | SCHERING CORPORATION (US) | 1989-12-27 | — | — | EP | disclosed |