Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 2/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9470503 | 0.95 | ALDH1A1 (0.40) | GAAALDH1A1MAPTPOLBHPGD | |
| SCHEMBL9470368 | 0.91 | ALDH1A1 (0.43) | GAAALDH1A1MAPTPOLBHPGD | |
| SCHEMBL4690229 | 0.90 | ALDH1A1 (0.34) | GAAALDH1A1MAPTPOLBHPGD | |
| SCHEMBL9469283 | 0.88 | ALDH1A1 (0.39) | GAAALDH1A1MAPTPOLBHPGD | |
| SCHEMBL9470466 | 0.87 | KMT2A (0.47) | GAAALDH1A1MAPTHPGDLMNA | |
| SCHEMBL9470300 | 0.87 | MAPT (0.39) | GAAALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL9470196 | 0.81 | ALDH1A1 (0.39) | GAAALDH1A1MAPTHPGDLMNA | |
| SCHEMBL9470115 | 0.80 | ALDH1A1 (0.45) | GAAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL9470341 | 0.78 | MEN1 (0.40) | GAAALDH1A1MAPTPOLBLMNA | |
| SCHEMBL9469535 | 0.78 | ALDH1A1 (0.50) | GAAALDH1A1MAPTPOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5182289-A | Pyrrolo 2,3-b!Pyridin-2-one Derivatives | SCHERING CORPORATION (US) | 1993-01-26 | — | — | US | disclosed |
| EP-0419561-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1991-04-03 | — | — | EP | disclosed |
| WO-1989012637-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1989-12-28 | — | — | WO | disclosed |
| EP-0347698-A1 | Heterobicyclic compounds having antiinflammatory activity | SCHERING CORPORATION (US) | 1989-12-27 | — | — | EP | disclosed |